RESUMO
Background: The erythrocyte sedimentation rate is the rate at which erythrocytes settle down when anticoagulated blood is allowed to stand in a vertical column for a particular period (usually during 1st. hour) and the length of fall of the top of the column of erythrocytes in the given interval of time determines the erythrocytes sedimentation rate. The micro methods of estimation of ESR and PCV have been developed to overcome the drawbacks of macro methods, especially of taking blood sample by venepuncture. Methods: The present study was undertaken to compare ESR and PCV values as estimated by macro and micro methods in diseased and healthy subjects to define the cut off levels of ESR and PCV (Micro method) for the children and adults. When the mean values and the various percentiles obtained by micro method were compared with that of macro method, in healthy and diseased children, healthy and diseased male and female adults, none of them showed any statiscal significant difference. Results: The results of hematocrits by both methods on individual basis were compared. Conclusion: It was noticed that there was a close approximation of the readings in each case in micro and macro methods
RESUMO
Background: Abnormalities in plasma lipoproteins and deranged lipid metabolism rank as most firmly established and best understood risk factor for atherosclerosis Lipid regulating drugs, may be prescribed if, dietary therapy and lifestyle modification fails to adequately normalize blood lipid levels. The European / Atherosclerosis Society and National Cholesterol Education Programme (NCEP) consider fibric acid derivatives (Fibrates) and Hydroxy Methylglutaryl CoA reductase inhibitors (HMG CoA reductase inhibitors) to be effective therapy for combined dyslipidernia . The aim of present study was to compare the efficacy of Atorvastatin and Fenofibrate on various aspects of lipid profile viz. total cholesterol, serum LDL-C, serum VLDL, serum HDL-C and serum triglycerides in Indian patients having dyslipidemia. Methods: This study was conducted on 100 patients with abnormal lipid profile attending the OPD/Wards of Department of Medicine, Guru Nanak Dev Hospital, attached to Government Medical College, Amritsar. Results: The patients were randomly divided into 2 groups of 50 each, group A and B. Group A were put on Atorvastatin 10-20 mg daily and Group B were put on micronized Fenofibrate 200mg daily. Conclusion: The study concluded that none of these drugs were independently able to achieve NCEP ATP III goals. Atorvastatin has main effect or total serum cholesterol and LDL-C whereas Fenofibrate has main effect on serum triglycerides, VLDL-C and HDL-C .Combination of these may be tried to achieve the desired goal.